Product Portfolio Overview Partnering With You To Drive Discovery

PROTEINS ANTIBODIES Over 5000 biologically active recombinant and natural proteins spanning 35 species.

Over 155,000 antibodies.

CONFIDENCE IN YOUR PURCHASE • Our antibodies are 100% guaranteed to work in the application and species listed.

• Ensure reproducibility based on our 5 Pillars of Validation testing, including Knockout Validation.

UNIQUE CLONES AND EXCLUSIVE ANTIBODIES • Many of our unique clones have been used by HLDA to establish CD nomenclature and we offer over 15,000 antibodies that

are available exclusively from us.

WIDE SELECTION OF CONJUGATED ANTIBODIES • We offer over 50,000 antibodies conjugated to at least 14 complimentary colors.

MONOCLONAL ANTIBODY PANELS • Thousands of non-catalog monoclonal antibodies available now. Test these panels in your application to find the

clone that produces optimal results.

RECOMBINANT ANTIBODY CONVERSION & ENGINEERING SERVICES • We have generated hundreds of recombinant antibodies, as listed in our catalog. Let our experts convert your hybridoma to an

immortalized recombinant antibody and even engineer modifications such as species, isotype, and Fc regions.

CUSTOM ANTIBODY DEVELOPMENT • Generate custom monoclonal or polyclonal antibodies, from immunogen design to purified antibody specificity screening, by

partnering with our expert development team.

Learn more | rndsystems.com/proteins Learn more | rndsystems.com/antibodies novusbio.com

QUALITY • Stringent quality control specifications for activity, purity, and endotoxin.

• More citations than any other protein manufacturer.

• Lot-to-lot consistency.

• Unmatched customer support.

SELECTION • Cytokines, receptors, proteases, and enzymes for metabolism and glycobiology research.

• Tags to meet needs: His, Fc, Biotin, Avi, and more.

• More than 10,000 non-catalog proteins available.

GMP CYTOKINES AND GROWTH FACTORS • Made specifically for cell-based clinical manufacturing.

• ISO 9001, ISO 13485-certified facility.

• Animal-free manufacturing.

• Focus on consistency, safety, and supply chain.

• Global experience.

CUSTOM DEVELOPMENT • Experience with a wide range of protein classes.

• New proteins from scratch.

• RUO to GMP conversion for ex vivo clinical manufacturing.

• Formulation to meet your requirements.

• Dedicated project managers.

https://www.rndsystems.com/products/proteins https://www.rndsystems.com/products/antibodies https://www.novusbio.com

SMALL MOLECULES Over 4500 high quality chemical tools for Cancer, Stem Cells, Neuroscience, Immunology, and Targeted Protein Degradation plus Fluorescent Dyes & Probes and Compound Libraries.

CUSTOM PRODUCTS & CONTRACT SERVICES

Learn more | rndsystems.com/custom

Expedite your research. Partnering with our industry-renowned product development and biomarker testing scientists to deliver unique reagents and reliable data.

Learn more | tocris.com

BE AT THE FOREFRONT OF RESEARCH • From the latest exclusively licensed research tools to established biochemical standards.

UNRIVALED PRODUCT QUALITY • High purity products and ISO 9001-certified facility.

FULLY ANNOTATED COMPOUNDS • The biological activity of all products is supported by peer reviewed publications.

COMPETITIVE PRICING • High end products priced to maximize your research budget.

CUSTOM PROTEIN & ANTIBODY GENERATION • Our recombinant technologies provide gram quantities of consistent proteins

and antibodies required for diagnostic and therapeutic reagent development.

ASSAY DEVELOPMENT • R&D Systems has over 20 years of experience developing, optimizing, and

validating immunoassay kits and Luminex® assays to ensure the highest level of performance in analyte quantification.

BIOMARKER & BIOACTIVITY TESTING SERVICES • Entrusting our experts with your clinical study samples ensures accurate results

that are returned in a timely, efficient, regulatory compliant, and confidential manner.

https://www.rndsystems.com/services https://www.tocris.com

Experts in developing tools for advancing stem cell and 3-D cell culture.

Grow healthy and robust cells with our full cell culture workflow portfolio.

CELL CULTURE ESSENTIALSSTEM CELL AND ORGANOIDS

WE HAVE YOU COVERED • Through reprogramming, expansion,

differentiation, and characterization we have tools to make your stem cell, organoid, and 3-D cell culture more efficient and reliable.

CONSISTENCY IS THE KEY • Reagent consistency is critical in reducing model variability,

ultimately saving you time and enabling more confident data analysis. From growth factors and serum-free media supplements to advanced tools for stem cell and organoid generation, our portfolio helps researchers build consistent and robust cell culture models.

DON’T WAIT TO DIFFERENTIATE • Our all-in-one kits for the differentiation of ES/iPS cells, HSCs, MSCs, and NSCs make working with stem cells easy.

BUILD BETTER ORGANOIDS • Stay at the forefront of organoid and 3-D cell culture by utilizing our organoid reagent guide or by attending our innovative

organoid webinars and virtual symposia. Together we can improve organoid research, innovation, and consistency!

COMMITTED TO REGENERATIVE MEDICINE MANUFACTURING • Accelerate your path to the clinic using our GMP-compliant ancillary reagents and services for pluripotent, mesenchymal,

and hematopoietic stem cells. Let us help you get your therapy to market!

Learn more | rndsystems.com/stemcells

CULTURE WITH CONFIDENCE • From cell culture substrates and media

supplements to differentiation and cell behavior kits, our tools for cell culture are designed to ensure that in vitro and ex vivo experiments will perform optimally.

CELL CULTURE BASICS BY THE BEST • Kick start your culture consistency and performance using R&D Systems fetal bovine serum,

classical media, balanced salt solutions, media supplements, and antibiotics. Now it's easier than ever for you to generate media optimized for your cell of choice!

CUSTOM MEDIA MANUFACTURING • The right cell culture media goes a long way. You’ve done the legwork to identify the best media for your cells, now let

us help you expedite and standardize production. Inquire about our custom cell culture media manufacturing services to start the conversation.

OPTIMIZED KITS AND MEDIA SUPPLEMENTS • With high-quality growth factors, cytokines, small molecules, and matrix components at our disposal, we’ve designed

specialty media and kits for the growth and differentiation of immune cells, brain cells, stem cells, and more.

ACCELERATE YOUR CELL AND GENE THERAPY MANUFACTURING • Bio-Techne can help streamline your path from discovery to clinical manufacturing. From our GMP-grade growth factors,

cytokines, and small molecules to our innovative GMP-grade ExCellerate Media, our goal is to simplify and risk-reduce the cell culture manufacturing process.

Learn more | rndsystems.com/cellculture

https://www.rndsystems.com/products/stem-cell-products

Ubiquitin Related Discovery Tools

Inhibitors

Kits

DUBs

Ubiquitin & Ubiquitin-like

Modifiers

Animal-Free™ GMP-Grade

High Bioactivity

Custom Protein Development

High Purity

Quality

Lot-to-Lot Consistency

Bulk Available

Immune Checkpoint Avi-tag & Fluorescent Proteins

Cytokines & Growth Factors

Enzymes

PROTEINS Largest Offering

of Bioactive Proteins

R&D SYSTEMS

Single Cell Western

Lateral Flow

Knockout/Knockdown Validated

CyTOF-ready

Secondary Antibodies

ISO Controls

Application Validation

Conjugated

NorthernLights™

Multiple Fluorochromes

Biotin

WB

ELISA

B/N

Simple Western™

IHC/ICC

IF

CD

FC ChIP

IP AP

ANTIBODIES Over 155,000 Available

ZebrafishMultiple Species

Mouse

Human

Canine

Viral

Drosophila

Feline Porcine

Rat

Bovine

Streptavidin (SA)

HRP

Alk-Phos

R&D SYSTEMS NOVUS BIOLOGICALS

Parameter™ Kits

ELISpot

Fluorokine™ E Activity Assay

Quantikine™ HS

Quantikine™ IVD

QuantiGlo™

DuoSet™ Kits

Quantikine™ ELISAs

DuoSet™ IC Kits

Development Modules

Complete Kits

ELISAS Setting the Industry

Gold Standard

R&D SYSTEMS

No Specialized Equipment Needed

More than 100 Analytes at Once

Membrane-Based

Each Analyte Extensively Tested for Specificity

PROTEOME PROFILER

ARRAYS ™

R&D SYSTEMS

Growth Factors

Small Molecules

Cell Scaffolding Matrices

N21-MAX & N-2 Supplements

Organoids

Mesenchymal

Hematopoietic

Neural

Differentiation Kits

Pluripotency Verification Kits

iMEF Cells

ES/iPS Cells

STEM CELLS & 3-D MODELS

Culture. Differentiate. Verify. Investigate.

R&D SYSTEMS

Media Supplements Cell Behavior

Assays

Migration

Invasion

Proliferation Apoptosis

DNA Damage

Fetal Bovine Serum

Balanced Salt Solutions

Antibiotics/ Antimycotics

Cultrex® ECM & Basement Membrane Extracts

Cytokines

Growth Factors

Specialty Media Classical

Media

Grow Healthy & Robust Cells

CELL CULTURE ESSENTIALS

R&D SYSTEMS

RNAscope™ Probes

Reagent Kits

Software & Quality Controls

Hybridization Systems

RNA ISH Detect Biomarkers

with Precision

ACD

Discovery Assays Performance Panels

Measure 50 Analytes Simultaneously

Multiple Species

Most Flexible

NHP Rat

Mouse

Human

Porcine

Most Accurate

Off-the-shelf Fixed Panels

Configure Your Panel

LUMINEX® Assays

R&D SYSTEMS

FLEXMAP™ 3D

Luminex®

Luminex 200™

Peggy Sue

Simple Western

SimplePlex

ProteinSimple™

Wes™

Ella

Milo™ Maurice™

Micro-Flow Imaging

FluorChem Imagers & AlphaImagers

Sally Sue

INSTRUMENTS Innovative Multi-analyte

Detection Platforms

R&D SYSTEMS PROTEINSIMPLE

Receptor Agonists & Antagonists

Enzyme Inhibitors

Caged Compounds

Fluorescent Probes & Dyes

Peptides

Compound Libraries

PROTAC® Ion Channel Modulators

SMALL MOLECULES

High Performance Life Science Reagents

TOCRIS BIOSCIENCE

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

LUMINEX® ASSAYS

Learn more | rndsystems.com/luminex

ELISAS

Learn more | rndsystems.com/elisas

LEGENDARY PERFORMANCE • Quantikine® ELISA kits set the industry gold standard in performance

and reproducibility. Results today can be compared to last month or even last year.

CONFIDENCE WITH CONTROLS • Our assays have available controls with assigned ranges which

guarantee performance.

ECONOMICAL ALTERNATIVES • Our DuoSet® and DuoSet® Intracellular (IC) ELISA Development

Systems provide the best signal-to-noise ratio for value-conscious labs.

700 analytes spanning 12 species. Choose from Discovery or High Performance

HIGH PERFOMANCE • Luminex High Performance Assays are the most accurate and precise bead-based multiplex assays for simultaneously

measuring up to 45 analytes from customizable panels in qualified complex matrices. You can select the panel format that best suits your needs, from off-the-shelf fixed panels or configurable premixed and user mixed options.

UNIQUELY FLEXIBLE ASSAY OPTIONS • Our Luminex Discovery Assays are the only premixed assays on the market where you can custom build your panel from over

450 analytes and receive it quickly. Create your own unique panel of up to 50 analytes which are then fully quality controlled for compatibility before shipment.

RESULTS YOU CAN TRUST • We are the immunoassay experts with 35 years of experience using our internally manufactured antibodies in developing

assay conditions and diluents to protect against false positives.

COMPLETE YOUR PANEL OF ANALYTES • Take advantage of our massive in-house collection of antibodies and proteins. Complete your panel with a custom development

order.

https://www.rndsystems.com/luminex/analytes https://www.rndsystems.com/products/elisas

We outperform the competition.

ELISPOT ANTIBODY ARRAYS Cast a wide net and stretch your dollar.

Learn more | rndsystems.com/elispot

CAN YOU RUN A WESTERN BLOT? • If the answer is yes, then you have all the equipment you need to use our antibody arrays.

USER-FRIENDLY DESIGN • Each array is stamped with an identification number for easy record keeping and contains

reference spots in three corners for orientation purposes.

COST-EFFECTIVE SCREENING • Each array offers a quick and inexpensive analysis of many analytes simultaneously, in less time

than it takes to perform a Western blot.

Learn more | rndsystems.com/proteomeprofiler

BE CONFIDENT IN THE DATA • Small, crisp spots all for easier more accurate quantitation and the largest dynamic range (number of detectable spots/well) on

the market.

DETECT LOW FREQUENCY RESPONSES • Our kits can measure responses with frequencies well below 1 in 100,000 cells – up to 20% more sensitive than our competition.

BE ASSURED THE KIT WORKED • We are the only company that provides recombinant protein positive controls.

https://www.rndsystems.com/products/elispot-kits-fluorospot-kits https://www.rndsystems.com/products/proteome-profiler-antibody-arrays

LUMINEX® 200™ • Simultaneously multiplex up to 100 analytes.

• Analyzes 96-well plate in 45 minutes.

• Dynamic range ≥ 4.5 logs.

FLEXMAP 3D® • Most advanced and versatile multiplexing system.

• Compatible with 96- and 384-well plates.

• Simultaneously multiplex up to 500 analytes.

• Quick read time of 20 minutes for 96-well plate and 75 minutes for 384-well plate.

• Ideal platform for high-throughput applications with compatible with front-end automation systems.

ELLA RUNS SIMPLE PLEX™ ASSAYS • Run up to 4 immunoassays from 25 uL of sample, with no

cross-reactivity.

• Set up samples in 10 minutes, get data in 1 hour.

• Get highly sensitive results at <10% CV.

• Choose from up to 150 validated targets, from cytokines to PD-L1.

WES™, PEGGY SUE™ AND SALLY SUE™ RUN SIMPLE WESTERN™ ASSAYS • Separation by capillary electrophoresis and immunodetection

of proteins from 2–440 kDa or by charge (IEF).

• No gel, blots and minimal hands-on are required.

• Sample to results in as little as 3 hours with Wes.

• Quantifiable and reproducible data.

MILO™ • Milo does Single-Cell Westerns to measure protein expression

in ~1,000 single cells in a single run.

• Multiplex to measure ~4 proteins in each single-cell.

• Use off-the-shelf, Western-validated antibodies to measure intracellular proteins or targets that don't have good flow antibodies.

• Identify cell subtypes that aren’t visible in traditional Westerns or get direct protein validation of your single-cell RNA results.

MAURICE • Next generation analytical platform for protein-based

biopharmaceutical products.

• cIEF or CE-SDS data in a snap.

• Novel native fluorescence detection provides increased cIEF sensitivity.

• Proprietary ready-to-use cartridge for unparalleled ease-of-use.

MICRO-FLOW IMAGING™ (MFI) • Image based analysis for sub-visible particles.

• Highly sensitive detection for translucent particles.

• Morphological measurements to distinguish different particle populations.

• Walk-away automation for up to 90 samples.

FLUORCHEM™ IMAGERS AND ALPHAIMAGERS • High quality digital imaging and analysis for protein/DNA gels

and Western blots.

• Cover a wide range of applications, from colony counting to multicolor fluorescent Westerns.

• Easy-to-use, versatile systems with powerful analysis software.

• Numerous excitation and emission options.

Global info@bio-techne.com bio-techne.com/find-us/distributors

North America TEL 800 343 7475

Europe | Middle East | Africa TEL +44 (0)1235 529449

China info.cn@bio-techne.com TEL +86 (21) 52380373

For research use or manufacturing purposes only. Trademarks and registered

trademarks are the property of their respective owners.

Bio-Techne® | R&D Systems™ Novus Biologicals™ Tocris Bioscience™ ProteinSimple™ ACD™ ExosomeDx™ Asuragen®

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